Keeping Your Brain Fit: The Enzyme Connection
5-min read
I came across this really interesting article in 2020 that still sticks with me.
If you’ve ever needed extra motivation to get moving, consider this a wake-up call from your future self. In this study, researchers discovered something fascinating: an enzyme called GPLD1 that’s released by the liver during exercise might help our brains stay sharp—well into our golden years. Studies on older mice showed that higher levels of GPLD1 (not to be confused with the now popular weight loss hormone, GLP-1), stimulated by exercise, were associated with improved memory and cognitive function. The truly exciting part? A consistent fitness routine could set you up to reap these benefits naturally, without waiting for a pill to be developed.
A Growing Brain—At Any Age
For a long time, scientists believed that our brains were more or less fixed in size and capability once we reached adulthood. But newer evidence has turned that assumption on its head. Researchers found that certain regions of the brain can continue to grow, even in older adults. As Saul Villeda from the University of California, San Francisco, notes:
"Just because you have an old brain, it doesn’t have to stay that way. One of the best-known interventions that has a benefit on the brain is exercise. The problem is many of the elderly are frail. They can’t physically do the exercise.”
In this particular study, researchers examined how exercise in older mice led to the production of more GPLD1, an enzyme primarily released by the liver into the bloodstream. Remarkably, older mice with heightened GPLD1 levels demonstrated better memory and cognition—abilities more in line with their younger counterparts.
Why Start Now?
Here’s the crucial takeaway: if you maintain a regular exercise routine now—whatever your current age or fitness level—you’re essentially building a foundation for successful aging. Yes, you! I’m calling you “young” because if you start today, you’re far more likely to keep the habit going and stay physically capable well into your later years.
Exercise consistency leads to better heart health, stronger muscles, and improved balance—factors that will help keep you active as you age. But it may also help you keep your brain in better shape, thanks to GPLD1 and other benefits we gain from being physically active. It’s good news all around: you don’t have to wait for scientists to finalize a new supplement or medication. Start moving more right now, and you’re giving your body and brain a head start.
What Does “Exercise” Mean for You?
Exercise is about far more than maintaining physical strength or managing your weight—it’s a powerful way to nurture your brain’s well-being. Every time you engage your body, whether through a brisk walk, a gentle dance session, or even light stretching, you set into motion internal processes that can benefit your mind. From stimulating the release of enzymes like GPLD1 to boosting blood flow, movement is key to supporting healthy brain function.
Crucially, exercise doesn’t have to be extreme or complicated to make a difference. It’s about adopting a lifestyle that includes regular, enjoyable activity. When you do something you love—be it gardening, swimming, or tai chi—you’re far more likely to keep at it, and your brain reaps the rewards of that consistency.
Consistency is Key
Sticking to regular exercise habits can strengthen the connection between your body and mind. As you commit to moving more, you also reinforce the neural pathways involved in learning and memory, potentially reducing the risk of age-related cognitive decline over time. Consistency doesn’t mean never missing a day—it means steadily returning to your chosen activities, even if you must adjust the intensity or frequency.
So, celebrate every step you take, every new movement you try, and every time you consciously choose to be active. By focusing on consistency rather than perfection, you’re setting the stage for a lifetime of benefits for both your brain and body.
Looking Ahead
Researchers are still exploring the full potential of GPLD1—especially how it might be used to regenerate parts of the aging brain or reduce inflammation that contributes to cognitive decline. But rather than wait for a breakthrough in a bottle, seize the benefits of exercise right now! By building—and keeping—a routine, you’ll be safeguarding your physical mobility and your cognitive function for years to come.
Maintaining an active lifestyle as you age doesn’t just happen by chance; it’s the cumulative effect of good habits built over time. And that’s the wonderful news: you already have the power to influence the health of your brain and body.
So lace up those sneakers, roll out that yoga mat, or dust off those dumbbells—every step, stretch, and squat you do is an investment in a brighter, stronger future for your mind and your body. Here’s to making every year a healthier one!
Unsure of where to start your fitness journey? Or need some regular accountability to keep that consistency? Schedule a FREE Strategy Session and we’ll work together to find what path may be best for you. Whether that’s with in-person session, or fully virtual coaching via my app, I’m here for you.
